A 2008-2009 Amazing Spider-Man storyline following the One More Day arc. Written by Dan Slott, Marc Guggenheim, Bob Gale, and Zeb Wells with art by Steve McNiven, Phil Jimenez, and others.
The arc spans issues #546-564 and #568-588, effectively making the series a thrice-monthly publication. It introduced new characters like Mister Negative and Menace while revitalizing classic villains.