B.P.R.D.: The Universal Machine #2 was published by Dark Horse Comics on May 1, 2006, as part of a series that began in 2006. John Arcudi and Mike Mignola write, and art comes from Dave Stewart and Guy Davis. This 32-page issue features Abe Sapien, Elizabeth Sherman, Dr. Kate Corrigan, Johann Kraus and Andrew Devon, among 11 characters cataloged on VerseDB.