A key issue noted for First appearance of Luke Carlyle. The Amazing Spider-Man #43 was published by Marvel Comics on September 1, 2002, as part of a series that began in 1999. J. Michael Straczynski writes, and art comes from Dan Kemp, John Romita Jr. and Scott Hanna. This 36-page issue features Spider-Man, Mary Jane, Aunt May, Doctor Octopus and Carlyle.