Secret Defenders #21 was published by Marvel Comics on November 1, 1994, as part of a series that began in 1993. Mike Kanterovich and Tom Brevoort write, and art comes from Bill Wylie, Jim Hoston and Michael Bair. This 36-page issue features Spider-Woman, U.S.Agent, Julia Carpenter, Doctor Druid and Rachel Carpenter, among 10 characters cataloged on VerseDB.